Ionizing Radiation Enhances Activity of Angiotensin-Converting Enzyme in Rat Aorta
- 作者: Samokhvalova T.1, Shaposhnikova V.1, Korystov Y.1, Korystova A.1, Kublik L.1, Levitman M.1
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隶属关系:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- 期: 卷 165, 编号 2 (2018)
- 页面: 216-219
- 栏目: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/240175
- DOI: https://doi.org/10.1007/s10517-018-4133-7
- ID: 240175
如何引用文章
详细
We analyzed changes in angiotensin-converting enzyme activity in rat aorta at the early terms after irradiation in doses equal to one fraction dose used in tumor radiotherapy. Male Wistar rats were exposed to whole body or local (chest) X-ray irradiation (200 kV, 1-7.5 Gy). The activity of the enzyme in aorta segments was measured in 1-48 h after irradiation by hydrolysis of hippuryl-histidine-leucine. Activity of angiotensin-converting enzyme in rat aorta was increased 1-24 h after whole body irradiation in a dose of 2.5 Gy with a peak in 2 h after exposure. After local exposure, enzyme activity also increased in 2 h, but returned to the control level in 24 h. In 2 h after whole-body irradiation in doses >2.5 Gy, the increase in enzyme activity was less pronounced and after exposure to 7.5 Gy, it did not differ from the control. During local exposure, the effect did not decrease with increasing the irradiation dose. The fraction of blood monocytes adherent to plastic in rats subjected to whole body irradiation decreases with increasing the dose. In rats subjected to local irradiation in a dose of 7.5 Gy, monocyte adhesion to plastic did not differ from the control. These data suggest that the increase in activity of angiotensin-converting enzyme in the aorta after irradiation is determined by monocyte adhesion to the endothelium; the decrease in this effects with increasing the dose can be explained by radiation damage of monocytes.
作者简介
T. Samokhvalova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino, Moscow Region
V. Shaposhnikova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino, Moscow Region
Yu. Korystov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino, Moscow Region
A. Korystova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino, Moscow Region
L. Kublik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino, Moscow Region
M. Levitman
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino, Moscow Region