Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats
- 作者: Butkevich I.1, Mikhailenko V.1
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隶属关系:
- Laboratory on Ontogenesis of Nervous System, I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences
- 期: 卷 165, 编号 2 (2018)
- 页面: 209-212
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240168
- DOI: https://doi.org/10.1007/s10517-018-4131-9
- ID: 240168
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详细
We studied the effect of chronic injections of serotonin reuptake inhibitor fluoxetine to rats during pregnancy on physiological and behavioral characteristics of female offspring during the prepubertal period. Fluoxetine reduced body weight in newborn females, but this parameter was restored to normal values by the age of 25 days. Fluoxetine also increased animal anxiety, but did not change the level of depressive behavior and cognitive capacities. It was shown that chronic injections of physiological solution to pregnant female enhanced nociceptive responses in the offspring during the prepubertal period, while fluoxetine neutralized the consequences of invasive intervention, which was expressed in a lower level of pain reaction in the offspring. This indicates the antinociceptive effect of fluoxetine.
作者简介
I. Butkevich
Laboratory on Ontogenesis of Nervous System, I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: irinabutkevich@yandex.ru
俄罗斯联邦, St. Petersburg
V. Mikhailenko
Laboratory on Ontogenesis of Nervous System, I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences
Email: irinabutkevich@yandex.ru
俄罗斯联邦, St. Petersburg