Measuring of Adhesion Force in the Cell—Cell System Based on Atomic Force Microscopy Technology
- 作者: Skorkina M.1, Shamray E.1, Sladkova E.1
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隶属关系:
- Belgorod State National Research University
- 期: 卷 164, 编号 4 (2018)
- 页面: 528-529
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239731
- DOI: https://doi.org/10.1007/s10517-018-4026-9
- ID: 239731
如何引用文章
详细
We developed and tested a method for fabrication of a biosensor chip based on native human whole blood lymphocyte and a titanium tipless cantilever. The biosensor can be used for measuring intermolecular adhesion forces in the cell—cell system by using atomic force spectroscopy. The developed biosensor chip was applied for measuring adhesion force between lymphocyte and granulocyte and between lymphocyte and erythrocyte in healthy individuals and in patients with acute lymphoblastic leukemia (before treatment, during standard treatment, and during relapse). It was found that adhesion force between lymphocyte and granulocyte and between lymphocyte and erythrocyte increased almost twice during relapse, which is an important diagnostic marker of early cytological abnormalities indicating progression of the disease.
作者简介
M. Skorkina
Belgorod State National Research University
编辑信件的主要联系方式.
Email: skorkina@bsu.edu.ru
俄罗斯联邦, Belgorod
E. Shamray
Belgorod State National Research University
Email: skorkina@bsu.edu.ru
俄罗斯联邦, Belgorod
E. Sladkova
Belgorod State National Research University
Email: skorkina@bsu.edu.ru
俄罗斯联邦, Belgorod
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