Signal Mechanism of the Protective Effect of Combined Preconditioning by Amtizole and Moderate Hypoxia
- 作者: Levchenkova O.1, Novikov V.1, Abramova E.1, Feoktistova Z.1
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隶属关系:
- Department of Pharmacology, Smolensk State Medical University
- 期: 卷 164, 编号 3 (2018)
- 页面: 320-323
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239575
- DOI: https://doi.org/10.1007/s10517-018-3981-5
- ID: 239575
如何引用文章
详细
The content of regulatory proteins involved in adaptation to hypoxia and ischemia was studied in brain rat homogenate under conditions of normoxia and after bilateral ligation of the common carotid arteries. Preconditioning with amtizole in combination with moderate hypoxia increased the levels of HIF-1α, erythropoietin, vascular endothelial growth factor under conditions of normoxia. During experimental ischemia, combined preconditioning led to stabilization of the content of these regulatory proteins at the level of intact control and to a decrease in glycogen synthase-3β kinase activity. This pattern of changes in regulatory proteins was noted during the early and late periods of preconditioning.
作者简介
O. Levchenkova
Department of Pharmacology, Smolensk State Medical University
编辑信件的主要联系方式.
Email: os.levchenkova@gmail.com
俄罗斯联邦, Smolensk
V. Novikov
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
俄罗斯联邦, Smolensk
E. Abramova
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
俄罗斯联邦, Smolensk
Zh. Feoktistova
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
俄罗斯联邦, Smolensk