Modeling of Lymphogenous and Hematogenous Metastasizing from Murine В16 Melanoma in Rats
- 作者: Kit O.1, Kaplieva I.1, Frantsiyants E.1, Trepitaki L.1
-
隶属关系:
- Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
- 期: 卷 163, 编号 6 (2017)
- 页面: 793-795
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239270
- DOI: https://doi.org/10.1007/s10517-017-3905-9
- ID: 239270
如何引用文章
详细
We developed a model of experimental melanoma. Intralienal xenogeneic transplantation of a suspension of melanoma cells B16 in physiological saline (0.1 ml; 1:10) was conducted to outbred male rats. In 6 months, histologically confirmed melanoma B16 in the spleen and its metastases in the liver, intestine, pancreas, adrenal glands, and lungs (hematogenous metastasis), as well as in the thymus and lymph nodes (lymphogenous metastasis) were revealed in rats. The proposed rat model of melanoma B16 metastasizes by the hematogenous and lymphogenous pathways, develops over 6 months, and allows receiving sufficient volume of material for analysis.
作者简介
O. Kit
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: kaplirina@yandex.ru
俄罗斯联邦, Rostov-on-Don
I. Kaplieva
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: kaplirina@yandex.ru
俄罗斯联邦, Rostov-on-Don
E. Frantsiyants
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: kaplirina@yandex.ru
俄罗斯联邦, Rostov-on-Don
L. Trepitaki
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: kaplirina@yandex.ru
俄罗斯联邦, Rostov-on-Don