Role of JAK1, JAK2, and JAK3 in Functional Stimulation of Mesenchymal Precursor Cells by Alkaloid Songorine

G. N. Zyuz’kov; E. V. Udut; L. A. Miroshnichenko; E. V. Simanina; T. Yu. Polyakova; L. A. Stavrova; V. V. Udut; M. Yu. Minakova; A. M. Dygai; A. V. Chaikovskii; V. I. Agafonov; V. V. Zhdanov

doi:10.1007/s10517-017-3824-9

Role of JAK1, JAK2, and JAK3 in Functional Stimulation of Mesenchymal Precursor Cells by Alkaloid Songorine

作者: Zyuz’kov G.¹^,2, Udut E.¹, Miroshnichenko L.¹, Simanina E.¹, Polyakova T.¹, Stavrova L.¹, Udut V.¹^,2, Minakova M.¹, Dygai A.¹, Chaikovskii A.¹, Agafonov V.¹, Zhdanov V.¹
隶属关系:
1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
2. Laboratory of Modeling of Physical Processes in Biology and Medicine, National Research Tomsk State University
期: 卷 163, 编号 4 (2017)
页面: 443-446
栏目: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238974
DOI: https://doi.org/10.1007/s10517-017-3824-9
ID: 238974

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详细

We studied the role of some JAK in the effect of diterpene alkaloid songorine on realization of the growth potential of mesenchymal precursor cells. The participation of JAK1, JAK2, and JAK3 in stimulation of proliferation of the precursor cells was demonstrated. Specific inhibitors of these JAK reduced the yield of fibroblast CFU and the rate of their division. Inhibition of JAK2 against the background of songorine treatment increased the rate of precursor differentiation.

作者简介

G. Zyuz’kov

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Laboratory of Modeling of Physical Processes in Biology and Medicine, National Research Tomsk State University

编辑信件的主要联系方式.
Email: zgn@pharmso.ru
俄罗斯联邦, Tomsk; Tomsk