Effect of Noradrenergic Neurotoxin DSP-4 and Maprotiline on Heart Rate Spectral Components in Stressed and Resting Rats
- 作者: Kur’yanova E.1, Zhukova Y.1, Teplyi D.1
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隶属关系:
- Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
- 期: 卷 163, 编号 3 (2017)
- 页面: 302-306
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238845
- DOI: https://doi.org/10.1007/s10517-017-3790-2
- ID: 238845
如何引用文章
详细
The effects of intraperitoneal DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, a noradrenergic neurotoxin) and maprotiline (an inhibitor of norepinephrine reuptake in synapses) on spectral components of heart rhythm variability were examined in outbred male and female rats treated with these agents in daily doses of 10 mg/kg for 3 days. At rest, DSP-4 elevated LF and VLF spectral components in male and female rats. Maprotiline elevated LF and VLF components in males at rest, increased HR and reduced all spectral components in resting females. Stress against the background of DSP-4 treatment sharply increased heart rate and reduced the powers of all spectral components (especially LF and VLF components). In maprotiline-treated rats, stress increased the powers of LF and VLF components. Thus, the central noradrenergic system participates in the formation of LF and VLF spectral components of heart rate variability at rest and especially during stressful stimulation, which can determine the phasic character of changes in the heart rate variability observed in stressed organism.
作者简介
E. Kur’yanova
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
编辑信件的主要联系方式.
Email: fyzevk@rambler.ru
俄罗斯联邦, Astrakhan
Yu. Zhukova
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
Email: fyzevk@rambler.ru
俄罗斯联邦, Astrakhan
D. Teplyi
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
Email: fyzevk@rambler.ru
俄罗斯联邦, Astrakhan
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