Proteomic Characteristics of Blood Serum in Rats with Different Behavioral Parameters after Acute Stress
- 作者: Kirbaeva N.1, Sharanova N.1, Vasil’ev A.1, Pertsov S.2,3
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隶属关系:
- Research Institute of Nutrition
- P. K. Anokhin Research Institute of Normal Physiology
- A. E. Evdokimov Moscow State University of Medicine and Density
- 期: 卷 162, 编号 5 (2017)
- 页面: 602-605
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238400
- DOI: https://doi.org/10.1007/s10517-017-3667-4
- ID: 238400
如何引用文章
详细
We studied proteome profile of blood serum of Wistar rats with different behavioral activity immediately and in 1 and 3 days after acute stress on the model of 12-h immobilization during the nighttime. Comparative analysis of 2D-electrophoretograms revealed differences in the expression of serum proteins in non-stressed (control) and stressed (experimental) rats. We found 22 protein spots that characterized the proteomic features of blood serum in rats with different prognostic resistance to stress. Mass-spectrometry of isolated spots identified 6 functional proteins. Persistent proteome changes in the blood of animals at different stages after acute stress were determined. The specificity of proteomic characteristics of blood serum was shown in behaviorally passive and active rats during the post-stress period. These data extend the concept on specific protein markers for the formation of a negative emotional state and adaptive-and-compensatory processes in mammals with different sensitivity to stressogenic factors.
作者简介
N. Kirbaeva
Research Institute of Nutrition
编辑信件的主要联系方式.
Email: n.kirbaeva@gmail.com
俄罗斯联邦, Moscow
N. Sharanova
Research Institute of Nutrition
Email: n.kirbaeva@gmail.com
俄罗斯联邦, Moscow
A. Vasil’ev
Research Institute of Nutrition
Email: n.kirbaeva@gmail.com
俄罗斯联邦, Moscow
S. Pertsov
P. K. Anokhin Research Institute of Normal Physiology; A. E. Evdokimov Moscow State University of Medicine and Density
Email: n.kirbaeva@gmail.com
俄罗斯联邦, Moscow; Moscow