Involvement of Glycogen Synthase Kinase-3 in the Mechanisms of Conditioned Food Aversion Memory Reconsolidation
- 作者: Nikitin V.1, Solntseva S.1, Kozyrev S.1
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隶属关系:
- P. K. Anokhin Research Institute of Normal Physiology
- 期: 卷 162, 编号 4 (2017)
- 页面: 413-417
- 栏目: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238270
- DOI: https://doi.org/10.1007/s10517-017-3628-y
- ID: 238270
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详细
Experiments were performed on the snails trained in conditioned food aversion for 3 days. Injection of TDZD-8 (glycogen synthase kinase-3 inhibitor, 2 mg/kg) in combination with reminder (presentation of a conditioned food stimulus) led to memory impairment developing 3 days after inhibitor/reminder exposure and followed by spontaneous recovery in 10 days. Injections of TDZD-8 in a dose of 4 or 20 mg/kg before reminder were shown to cause amnesia that persisted for more than 10 days. Memory recovery during repeated training was observed at the earlier period than after initial training. The impairment of memory reconsolidation by TDZD-8 after training of snails for 1 day was less pronounced than under standard training conditions (3 days). The effect of a glycogen synthase kinase-3 inhibitor during memory reconsolidation is probably followed by impairment of memory retrieval and/or partial loss, which can be compensated spontaneously or after repeated training.
作者简介
V. Nikitin
P. K. Anokhin Research Institute of Normal Physiology
编辑信件的主要联系方式.
Email: nikitin.vp@mail.ru
俄罗斯联邦, Moscow
S. Solntseva
P. K. Anokhin Research Institute of Normal Physiology
Email: nikitin.vp@mail.ru
俄罗斯联邦, Moscow
S. Kozyrev
P. K. Anokhin Research Institute of Normal Physiology
Email: nikitin.vp@mail.ru
俄罗斯联邦, Moscow