Altered Liver Proteoglycan/Glycosaminoglycan Structure as a Manifestation of Extracellular Matrix Remodeling upon BCG-induced Granulomatosis in Mice
- 作者: Kim L.1, Shkurupy V.2,1, Putyatina A.1
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隶属关系:
- Research Institute of Experimental and Clinical Medicine
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 162, 编号 3 (2017)
- 页面: 331-335
- 栏目: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/238176
- DOI: https://doi.org/10.1007/s10517-017-3608-2
- ID: 238176
如何引用文章
详细
Experimental BCG-induced granulomatosis in mice was used to study changes in the dynamics of individual liver proteoglycan components reflecting phasic extracellular matrix remodeling, determined by the host—parasite interaction and associated with granuloma development. In the early BCG-granulomatosis period, the increase in individual proteoglycan components promotes granuloma formation, providing conditions for mycobacteria adhesion to host cells, migration of phagocytic cells from circulation, and cell—cell interaction leading to granuloma development and fibrosis. Later, reduced reserve capacity of the extracellular matrix, development of interstitial fibrosis and granuloma fibrosis can lead to trophic shortage for cells within the granulomas, migration of macrophages out of them, and development of spontaneous necrosis and apoptosis typical of tuberculosis.
作者简介
L. Kim
Research Institute of Experimental and Clinical Medicine
编辑信件的主要联系方式.
Email: lenkim@centercem.ru
俄罗斯联邦, Novosibirsk
V. Shkurupy
Novosibirsk State Medical University, Ministry of Health of the Russian Federation; Research Institute of Experimental and Clinical Medicine
Email: lenkim@centercem.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
A. Putyatina
Research Institute of Experimental and Clinical Medicine
Email: lenkim@centercem.ru
俄罗斯联邦, Novosibirsk