Paradoxical Effect of NMDA Receptor Blockade in Chicks on Learning and Memory in Passive Avoidance Model
- 作者: Tiunova A.1, Komissarova N.1, Bezryadnov D.1, Anokhin K.1,2
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隶属关系:
- P. K. Anokhin Research Institute of Normal Physiology
- National Research Center Kurchatov Institute
- 期: 卷 162, 编号 1 (2016)
- 页面: 1-3
- 栏目: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237856
- DOI: https://doi.org/10.1007/s10517-016-3529-5
- ID: 237856
如何引用文章
详细
Activity of NMDA receptors is a prerequisite for numerous but not all forms of neuronal plasticity and learning. The present study examined the role of NMDA receptors in standard, weak, and repeated passive avoidance training in young chicks. Injection of MK-801, an antagonist of NMDA receptor, prior to strong training episode impaired subsequent memory recall. Moreover, repeated training did not restore the lost memory. In the double weak training protocol, the impairing effect of MK-801 was observed only when it was injected prior to the second but not to the first training episode. These results suggest that activation of NMDA receptors is not a necessary stage for memory acquisition in the weak training task. In contrast, the mechanisms of strong training depending on activation of NMDA receptors can be probably involved into the second training episode performed against the background of existing NMDA receptor-independent memory about the first training episode.
作者简介
A. Tiunova
P. K. Anokhin Research Institute of Normal Physiology
编辑信件的主要联系方式.
Email: aat699@yahoo.com
俄罗斯联邦, Moscow
N. Komissarova
P. K. Anokhin Research Institute of Normal Physiology
Email: aat699@yahoo.com
俄罗斯联邦, Moscow
D. Bezryadnov
P. K. Anokhin Research Institute of Normal Physiology
Email: aat699@yahoo.com
俄罗斯联邦, Moscow
K. Anokhin
P. K. Anokhin Research Institute of Normal Physiology; National Research Center Kurchatov Institute
Email: aat699@yahoo.com
俄罗斯联邦, Moscow; Moscow
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