Effect of Preliminary Injection of Bone Marrow Cell Total RNA on Erythropoiesis Recovery Dynamics in Rats Exposed to an Acute γ-Irradiation
- 作者: Gevorkyan N.1, Tishevskaya N.2, Bolotov A.2
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隶属关系:
- V. N. Orekhovich Research Institute of Biomedical Chemistry, the Russian Academy of Medical Sciences
- South Ural State Medical University
- 期: 卷 161, 编号 5 (2016)
- 页面: 723-726
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237716
- DOI: https://doi.org/10.1007/s10517-016-3494-z
- ID: 237716
如何引用文章
详细
Total RNA from the bone marrow of healthy donor rats was injected to experimental rats 6 h, 2 h, or 30 min prior to a single γ-irradiation in the sublethal dose of 6 Gy. Injection total RNA 30 min prior to the exposure most effectively restored erythropoiesis in experimental animals. In 5 days, reticulocyte count in these animals 30-fold surpassed the control (injection of 0.9% NaCl). In 12 days, the content of new erythroblastic islands in the bone marrow in rats injected with the total RNA 2 h or 30 min prior to irradiation increased significantly and erythropoiesis recovery activation was observed.
作者简介
N. Gevorkyan
V. N. Orekhovich Research Institute of Biomedical Chemistry, the Russian Academy of Medical Sciences
Email: natalya-tishevskaya@yandex.ru
俄罗斯联邦, Moscow
N. Tishevskaya
South Ural State Medical University
编辑信件的主要联系方式.
Email: natalya-tishevskaya@yandex.ru
俄罗斯联邦, Chelyabinsk
A. Bolotov
South Ural State Medical University
Email: natalya-tishevskaya@yandex.ru
俄罗斯联邦, Chelyabinsk