Antitumor Effects of JAK3 Inhibitor on the Model of Transplantable Lewis Lung Carcinoma and Mechanisms of Their Development
- 作者: Zyuz’kov G.1,2, Amosova E.1, Chaikovskii A.1, Miroshnichenko L.1, Udut E.1, Rybalkina O.1, Zhdanov V.1, Udut V.1,2, Dygai A.1, Zueva E.1
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隶属关系:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
- 期: 卷 161, 编号 3 (2016)
- 页面: 367-370
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237421
- DOI: https://doi.org/10.1007/s10517-016-3415-1
- ID: 237421
如何引用文章
详细
Mice with Lewis lung carcinoma were used to study the antitumor and antimetastatic effects of JAK3 inhibitor. The study revealed no effect of JAK3 inhibitor on the growth of primary tumor node, but found a pronounced inhibition of hematogenous spread of the pathologic process into the lungs. In vitro blockade of JAK3 in cultured Lewis lung carcinoma produced no effect on the count of the stem tumor cells and stimulated functions of committed elements. In addition, blockade of JAK3 significantly elevated maturation index of the tumor tissue.
作者简介
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
编辑信件的主要联系方式.
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk; Tomsk
E. Amosova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk
A. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk
O. Rybalkina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk
V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk; Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk
E. Zueva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
俄罗斯联邦, Tomsk
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