Changes in Behavior and Blood Corticosterone Level in Male and Female Rats after Single Administration of Obestatin Fragment 1-4

E. S. Motorykina; E. A. Khirazova; M. V. Maslova; A. V. Graf; A. S. Maklakova; A. A. Bayzhumanov; O. D. Kurko; L. A. Andreeva; N. A. Sokolova; N. F. Myasoedov; A. A. Kamenskii

doi:10.1007/s10517-016-3379-1

Changes in Behavior and Blood Corticosterone Level in Male and Female Rats after Single Administration of Obestatin Fragment 1-4

作者: Motorykina E.¹, Khirazova E.¹, Maslova M.¹, Graf A.¹, Maklakova A.¹, Bayzhumanov A.¹, Kurko O.¹, Andreeva L.¹, Sokolova N.¹, Myasoedov N.¹, Kamenskii A.¹
隶属关系:
1. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University
期: 卷 161, 编号 2 (2016)
页面: 218-220
栏目: Article
URL: https://journals.rcsi.science/0007-4888/article/view/237277
DOI: https://doi.org/10.1007/s10517-016-3379-1
ID: 237277

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Single administration of the obestatin fragment 1-4 (300 nmol/kg) to male Wistar rats produced a significant weight loss in male rats on observation days 5-8, while in female rats only on day 8. In addition, males demonstrated decreased risk factor in the elevated plus-maze test, but no effect of the preparation on behavior of female rats was revealed. Obestatin fragment 1-4 had no effect on corticosterone level 1 week after single administration in both females and male rats.