Effect of Factors Secreted by the Placenta on Phenotype of THP-1 Cells Cultured on a 3D Scaffold
- 作者: Lvova T.1, Stepanova O.1, Viazmina L.1, Okorokova L.1, Belyakova K.1, Belikova M.1, Selkov S.1, Sokolov D.1
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隶属关系:
- D. O. Ott Reseach Institute of Obstetrics and Gynecology
- 期: 卷 161, 编号 1 (2016)
- 页面: 162-167
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237223
- DOI: https://doi.org/10.1007/s10517-016-3368-4
- ID: 237223
如何引用文章
详细
We studied the effects of secretory products of the placenta obtained from women with normal pregnancy and preeclampsia on the expression of surface markers by THP-1 cells cultured on a 3D Matrigel scaffold. Secretory products of third trimester placentas obtained from women with normal pregnancy reduced the relative number of THP-1 cells expressing CD54 and CD14 molecules and expression of CD14 and CD95 molecules by THP-1 cells in comparison with the effect of secretory products first trimester placentas. In parallel, the intensity of CD49d expression by THP-1 cells increased in the presence of secretory products of third trimester placentas in comparison with the first trimester. No differences in the expression of the studied molecules by THP-1 cells under the effect of placentas from women with physiological pregnancy and patients with preeclampsia were found.
作者简介
T. Lvova
D. O. Ott Reseach Institute of Obstetrics and Gynecology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
O. Stepanova
D. O. Ott Reseach Institute of Obstetrics and Gynecology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
L. Viazmina
D. O. Ott Reseach Institute of Obstetrics and Gynecology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
L. Okorokova
D. O. Ott Reseach Institute of Obstetrics and Gynecology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
K. Belyakova
D. O. Ott Reseach Institute of Obstetrics and Gynecology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
M. Belikova
D. O. Ott Reseach Institute of Obstetrics and Gynecology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
S. Selkov
D. O. Ott Reseach Institute of Obstetrics and Gynecology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
D. Sokolov
D. O. Ott Reseach Institute of Obstetrics and Gynecology
编辑信件的主要联系方式.
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg