Inhibition of Mitochondrial Voltage-Dependent Anion Channels Increases Radiosensitivity of K562 Leukemic Cells
- 作者: Saenko Y.1, Mastilenko A.1, Glushchenko E.1, Antonova A.1, Svekolkin V.1
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隶属关系:
- Laboratory of Molecular and Cell Biology, S. P. Kapitsa Research Technology Institute, Ulyanovsk State University
- 期: 卷 161, 编号 1 (2016)
- 页面: 104-107
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237149
- DOI: https://doi.org/10.1007/s10517-016-3356-8
- ID: 237149
如何引用文章
详细
We studied the effect of inhibition of mitochondrial voltage-dependent anion channels with DIDS on radiosensitivity and mitochondrial status of K562 leukemic cells. The number of apoptotic and necrotic cells, mitochondrial transmembrane potential, and mitochondrial mass were evaluated after irradiation of cells in doses of 4 and 12 Gy in the presence and absence of the inhibitor. Inhibition of mitochondrial voltage-dependent anion channels increased radiosensitivity of K562 cells by 50-70% and decreased both mitochondrial transmembrane potential and mitochondrial mass. Inhibitors of voltage-dependent anion channels are promising agents capable of improving the effectiveness of cancer radiotherapy.
作者简介
Y. Saenko
Laboratory of Molecular and Cell Biology, S. P. Kapitsa Research Technology Institute, Ulyanovsk State University
编辑信件的主要联系方式.
Email: saenkoyv@yandex.ru
俄罗斯联邦, Ulyanovsk
A. Mastilenko
Laboratory of Molecular and Cell Biology, S. P. Kapitsa Research Technology Institute, Ulyanovsk State University
Email: saenkoyv@yandex.ru
俄罗斯联邦, Ulyanovsk
E. Glushchenko
Laboratory of Molecular and Cell Biology, S. P. Kapitsa Research Technology Institute, Ulyanovsk State University
Email: saenkoyv@yandex.ru
俄罗斯联邦, Ulyanovsk
A. Antonova
Laboratory of Molecular and Cell Biology, S. P. Kapitsa Research Technology Institute, Ulyanovsk State University
Email: saenkoyv@yandex.ru
俄罗斯联邦, Ulyanovsk
V. Svekolkin
Laboratory of Molecular and Cell Biology, S. P. Kapitsa Research Technology Institute, Ulyanovsk State University
Email: saenkoyv@yandex.ru
俄罗斯联邦, Ulyanovsk