State of Stress-Marker Organs in Rats after a Single Exposure to Long-Term Stress and Treatment with Lipopolysaccharide


Цитировать

Полный текст

Открытый доступ Открытый доступ
Доступ закрыт Доступ предоставлен
Доступ закрыт Только для подписчиков

Аннотация

We studied the effect of LPS on the state of stress-marker organs in rats at various periods after a single exposure to long-term stress on the model of 24-h immobilization. The animals were intraperitoneally injected with LPS in a dose of 100 μg/kg immediately after the negative emotiogenic exposure. Changes in physiological parameters were evaluated 3 h, 1 day, and 8 days after immune stimulation. Acute stress was accompanied by a decrease in the weight of the thymus during all stages of the post-stress period. An increase in the relative weight of theadrenal glands in animals under these conditions was observed only on day 8 after restraint stress. The induction of immune reactions due to systemic treatment with LPS was shown to prevent involution of the spleen in the late stage after a single exposure to long-term stress (day 8). Hypertrophy of the adrenal glands, which serves as one of the typical reactions of mammals to negative emotiogenic factors, was not revealed during the post-stress period after antigenic stimulation. These data hold much promise for the development of new approaches to the use of immunoactive substances to prevent or reduce the severity of physiological changes after emotiogenic loads.

Об авторах

I. Alekseeva

P. K. Anokhin Research Institute of Normal Physiology

Email: s.pertsov@mail.ru
Россия, Moscow

A. Abramova

P. K. Anokhin Research Institute of Normal Physiology; A. I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of the Russian Federation

Email: s.pertsov@mail.ru
Россия, Moscow; Moscow

A. Kozlov

P. K. Anokhin Research Institute of Normal Physiology; A. I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of the Russian Federation

Email: s.pertsov@mail.ru
Россия, Moscow; Moscow

E. Koplik

P. K. Anokhin Research Institute of Normal Physiology

Email: s.pertsov@mail.ru
Россия, Moscow

A. Pertsov

I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)

Email: s.pertsov@mail.ru
Россия, Moscow

D. Lyadov

P. K. Anokhin Research Institute of Normal Physiology; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)

Email: s.pertsov@mail.ru
Россия, Moscow; Moscow

E. Nikenina

P. K. Anokhin Research Institute of Normal Physiology

Email: s.pertsov@mail.ru
Россия, Moscow

S. Pertsov

P. K. Anokhin Research Institute of Normal Physiology; A. I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of the Russian Federation

Автор, ответственный за переписку.
Email: s.pertsov@mail.ru
Россия, Moscow; Moscow


© Springer Science+Business Media, LLC, part of Springer Nature, 2019

Данный сайт использует cookie-файлы

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.

О куки-файлах