Hepatoprotective Effect of Neonatal Administration of Non-Opioid Leu-Enkephalin Analogue in Adult Albino Rats Subjected to Antenatal Hypoxia
- Авторы: Pinaeva O.1, Lebed’ko O.1,2, Pinaev S.3, Sazonova E.1,2
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Учреждения:
- Far-Eastern State Medical University, Ministry of Health of the Russian Federation
- Khabarovsk Affiliated Branch of Far-Eastern Research Center of Respiratory Physiology and Pathology — Research Institute of Mother and Child Care
- Computing Center of Far-Eastern Branch of the Russian Academy of Sciences
- Выпуск: Том 167, № 4 (2019)
- Страницы: 428-431
- Раздел: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241777
- DOI: https://doi.org/10.1007/s10517-019-04542-9
- ID: 241777
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Аннотация
We studied the effects of neonatal administration of non-opioid leu-enkephalin analogue peptide NALE) on the morphological parameters of the liver and redox status of 60-dayold albino rats subjected to antenatal hypoxia. In animals subjected to antenatal hypoxia, a decrease body weight and reduction of the area of hepatocytes and total area of their nucleoli were observed; these changes were accompanied by activation of free-radical processes and impairment of antioxidant defense in the liver and blood serum. Intraperitoneal administration of NALE (100 μg/kg, daily) during postnatal days 2-6 normalized body weight, hepatocyte area, and total area of their nucleoli, significantly reduced the intensity of ROS generation, and improved antioxidant protection in the liver and blood serum in 60-day-old animals subjected to antenatal hypoxia.
Об авторах
O. Pinaeva
Far-Eastern State Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: pinaeva_og@mail.ru
Россия, Khabarovsk
O. Lebed’ko
Far-Eastern State Medical University, Ministry of Health of the Russian Federation; Khabarovsk Affiliated Branch of Far-Eastern Research Center of Respiratory Physiology and Pathology — Research Institute of Mother and Child Care
Email: pinaeva_og@mail.ru
Россия, Khabarovsk; Khabarovsk
S. Pinaev
Computing Center of Far-Eastern Branch of the Russian Academy of Sciences
Email: pinaeva_og@mail.ru
Россия, Khabarovsk
E. Sazonova
Far-Eastern State Medical University, Ministry of Health of the Russian Federation; Khabarovsk Affiliated Branch of Far-Eastern Research Center of Respiratory Physiology and Pathology — Research Institute of Mother and Child Care
Email: pinaeva_og@mail.ru
Россия, Khabarovsk; Khabarovsk
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