Effect of Interleukin-10 on Localization of AMPA Receptors in Synapses during Long-Term Posttetanic Potentiation in Cultured Hippocampal Slices
- Авторы: Mikheeva I.1, Malkov A.1, Pavlik L.1, Arkhipov V.1,2, Levin S.1,2
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Учреждения:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Pushchino State Institute of Natural Sciences
- Выпуск: Том 167, № 1 (2019)
- Страницы: 53-56
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241443
- DOI: https://doi.org/10.1007/s10517-019-04459-3
- ID: 241443
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Аннотация
The effect of the anti-inflammatory cytokine IL-10 on the ultrastructural distribution of AMPA receptor GluR1 subunit in CA1 field of cultured hippocampal slices was studied by using immunohistochemical technique. It was found that long-term posttetanic potentiation increased the content of GluR1 in the postsynaptic density of the axo-spinous synapse. Addition of IL-10 in concentrations of 1 and 10 ng/ml to the medium facilitated long-term posttetanic potentiation thereby changing the distribution of GluR1 in the spine: the number of receptors increased in the cytoplasm and decreased in the postsynaptic density. It is assumed that activation of neuronal IL-10 receptors affects the distribution of AMPA receptors in axo-spinous synapses of hippocampal field CA1 through interplay of intracellular signaling pathways, thereby participating in the mechanisms of synaptic plasticity under normal conditions.
Об авторах
I. Mikheeva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: mikheirina@yandex.ru
Россия, Pushchino, Moscow Region
A. Malkov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: mikheirina@yandex.ru
Россия, Pushchino, Moscow Region
L. Pavlik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: mikheirina@yandex.ru
Россия, Pushchino, Moscow Region
V. Arkhipov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: mikheirina@yandex.ru
Россия, Pushchino, Moscow Region; Pushchino, Moscow Region
S. Levin
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: mikheirina@yandex.ru
Россия, Pushchino, Moscow Region; Pushchino, Moscow Region