Inhibition of Meprins Reduces Pulmonary Edema in LPS-Induced Acute Lung Damage
- Авторы: Chepurnova D.1, Samoilova Е.1, Verin А.2, Fesenko A.1, Anisimov А.1, Korotaeva A.1
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Учреждения:
- National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
- Vascular Biology Center and Pulmonary Division at Augusta University
- Выпуск: Том 166, № 6 (2019)
- Страницы: 719-721
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241307
- DOI: https://doi.org/10.1007/s10517-019-04425-z
- ID: 241307
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Аннотация
Pulmonary edema is the major factor of tissue hypoxia in acute lung injury. Disruption of cell—cell contacts and lung interstitium increases permeability of the vascular endothelium and alveolar epithelium, which leads to the development of pulmonary edema. Meprin metalloproteases cleave extracellular matrix proteins, thus aggravating pulmonary edema. Meprin inhibitor actinonin was administered to rats with LPS-induced acute lung injury. Damaged lungs looked spotted and had multiple hemorrhage focuses, protein concentration in lavage fluid was increased, and lung weight coefficient was high. Administration of meprin inhibitor actinonin considerably reduced protein content in the bronchoalvelolar lavage and lung coefficient; only solitary lung hemorrhages were seen after this treatment. Thus, inhibition of meprins potentially alleviates LPS-induced disorders in the lung tissue permeability and reduces pulmonary edema.
Об авторах
D. Chepurnova
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
Email: erihter@mail.ru
Россия, Moscow
Е. Samoilova
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: erihter@mail.ru
Россия, Moscow
А. Verin
Vascular Biology Center and Pulmonary Division at Augusta University
Email: erihter@mail.ru
США, Augusta, GA
A. Fesenko
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
Email: erihter@mail.ru
Россия, Moscow
А. Anisimov
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
Email: erihter@mail.ru
Россия, Moscow
A. Korotaeva
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
Email: erihter@mail.ru
Россия, Moscow