Neurological Deficit and Structural Changes in Lymphoid Structures of the Tracheal Wall in the Immediate Stage of Experimental Hemorrhagic Stroke in Rats with Different Behavioral Activity
- Авторы: Klyueva L.1, Koplik E.2, Vasyanina K.1, Pertsov S.2,3
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Учреждения:
- I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
- P. K. Anokhin Research Institute of Normal Physiology
- I. A. Evdokimov Moscow State University of Medicine and Dentistry
- Выпуск: Том 166, № 6 (2019)
- Страницы: 714-718
- Раздел: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241304
- DOI: https://doi.org/10.1007/s10517-019-04424-0
- ID: 241304
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Аннотация
Specific features of neurological deficit and changes in the cellular composition of tracheal lymphoid structures during the immediate stage (day 1) of hemorrhagic stroke were studied in rats with various behavioral parameters. Modeling of hemorrhage in the left caudate nucleus of the brain was followed by the development of motor disturbances in the forelimb use asymmetry test and corner rotation paradigm. These animals preferred to use the left forelimb (ipsilateral to the side of hemorrhage) to lean on the cylinder wall. The frequency of using the right forelimb or both forelimbs was reduced under these conditions. The number of left-sided rotations increased, while the percentage of right-sided rotations decreased. The observed changes were accompanied by immune dysfunction. It was manifested in the depletion of lymphoid aggregates of the tracheal wall in lymphocytes and plasma cells. The severity of abnormal neurological symptoms and disturbances in immune homeostasis during the immediate stage of hemorrhagic stroke was greater in behaviorally passive rats than in active specimens.
Об авторах
L. Klyueva
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: moloko1978@gmail.com
Россия, Moscow
E. Koplik
P. K. Anokhin Research Institute of Normal Physiology
Email: moloko1978@gmail.com
Россия, Moscow
K. Vasyanina
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Email: moloko1978@gmail.com
Россия, Moscow
S. Pertsov
P. K. Anokhin Research Institute of Normal Physiology; I. A. Evdokimov Moscow State University of Medicine and Dentistry
Email: moloko1978@gmail.com
Россия, Moscow; Moscow