Effect of Atorvastatin Therapy on the Level of CD34+CD133+CD309+ Endothelial Progenitor Cells in Patients with Coronary Heart Disease
- Авторы: Ansheles A.1, Rvacheva A.1, Sergienko I.1
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Учреждения:
- Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
- Выпуск: Том 163, № 1 (2017)
- Страницы: 133-136
- Раздел: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/238708
- DOI: https://doi.org/10.1007/s10517-017-3753-7
- ID: 238708
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Аннотация
In 58 patients with coronary heart disease, the count of CD34+CD133+CD309+ endothelial progenitor cells in the blood was determined and the dynamics of the content of endothelial progenitor cells, angiogenic growth factors, and lipid parameters over 3 months of atorvastatin therapy was analyzed. Atorvastatin was administered in daily doses of 10 mg (26 patients) and 40 mg (32 patients). Control group comprised 15 healthy volunteers. In patients with coronary heart disease, the count of endothelial progenitor cells was lower by 4 times, the level of VEGF was higher by 52%, and the level of endostatin was lower by 13% than in healthy volunteers. Atorvastatin therapy significantly reduced the levels of VEGF (by 11%), C-reactive protein (by 26%), total cholesterol (by 30%), LDL cholesterol (by 35%), and triglycerides (by 18%); the levels of endostatin, MCP-1, and HDL cholesterol remained unchanged. The count of endothelial progenitor cells increased significantly by 72% irrespectively on the statin dose, but the changes were more pronounced in patients with lower initial endothelial progenitor cell counts and in patients with more drastic decrease in LDL cholesterol.
Об авторах
A. Ansheles
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: a.ansheles@gmail.com
Россия, Moscow
A. Rvacheva
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: a.ansheles@gmail.com
Россия, Moscow
I. Sergienko
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: a.ansheles@gmail.com
Россия, Moscow
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