Role of ATP-Sensitive K+ Channels in Myocardial Infarct Size-Limiting Effect of Chronic Continuous Normobaric Hypoxia
- Авторы: Lishmanov Y.1,2, Naryzhnaya N.1, Tsibul’nikov S.1,2, Wang H.3, Maslov L.1
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Учреждения:
- Research Institute of Cardiology, Tomsk Research Medical Center
- National Research Tomsk Polytechnic University
- Liaoning Medical College
- Выпуск: Том 163, № 1 (2017)
- Страницы: 22-24
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238618
- DOI: https://doi.org/10.1007/s10517-017-3728-8
- ID: 238618
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Аннотация
The role of KATP channels in myocardial infarct size-limiting effect of chronic continuous normobaric hypoxia was examined in a rat model based on a 20-min coronary occlusion and subsequent 3-h reperfusion. Rats were adapted to normobaric hypoxia (12% O2) for 21 days. This hypoxia produced a pronounced infarct size-limiting effect, which had been prevented by 0.3 mg/kg glibenclamide, a non-selective inhibitor of entire pool of KATP channels, or 5 mg/kg 5-hydroxydecanoate, an inhibitor of mitochondrial KATP channels. The study highlighted the important role of mitochondrial KATP channels in myocardial infarct size-limiting effect of chronic normobaric hypoxia.
Об авторах
Yu. Lishmanov
Research Institute of Cardiology, Tomsk Research Medical Center; National Research Tomsk Polytechnic University
Email: natalynar@yandex.ru
Россия, Tomsk; Tomsk
N. Naryzhnaya
Research Institute of Cardiology, Tomsk Research Medical Center
Автор, ответственный за переписку.
Email: natalynar@yandex.ru
Россия, Tomsk
S. Tsibul’nikov
Research Institute of Cardiology, Tomsk Research Medical Center; National Research Tomsk Polytechnic University
Email: natalynar@yandex.ru
Россия, Tomsk; Tomsk
H. Wang
Liaoning Medical College
Email: natalynar@yandex.ru
Китай, Jinzhou City, Liaoning Province
L. Maslov
Research Institute of Cardiology, Tomsk Research Medical Center
Email: natalynar@yandex.ru
Россия, Tomsk