New Xymedon Analogues for Stimulation of Posttraumatic Regeneration of the Spinal Cord in Rats
- Авторы: Povysheva T.1, Semenov V.1, Galyametdinova I.1, Reznik V.1, Knni K.2, Kolesnikov P.2, Chelyshev Y.2
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Учреждения:
- Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences
- Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation
- Выпуск: Том 162, № 2 (2016)
- Страницы: 220-224
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238053
- DOI: https://doi.org/10.1007/s10517-016-3580-2
- ID: 238053
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Аннотация
Effect of systemic administration of synthetic pyrimidine derivatives, xymedon and compounds 29D and 34D, was studied in rats with experimental dosed contusion spinal cord injury. Xymedon promoted recovery of motor function after injury. Compounds 29D and 34D more effectively restored the parameters of open-field and Rotarod tests in comparison with xymedon. Compound 29D more effectively than xymedon maintained the number of Olig2+ oligodendrocytes in the corticospinal tract and NG2 cells in all investigated areas of the white matter. In the group treated with compound 34D, the differences in the number of NG2+ cells were revealed only in the anterior funiculi, where the number of these glial cells was 2-fold higher than in the xymedon-treated group. Obtained results suggest that the studied xymedon analogs, compounds 29D and 34D, can exert their therapeutic action through different molecular and cellular pathways.
Об авторах
T. Povysheva
Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences
Автор, ответственный за переписку.
Email: t.povysheva@gmail.com
Россия, Kazan
V. Semenov
Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences
Email: t.povysheva@gmail.com
Россия, Kazan
I. Galyametdinova
Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences
Email: t.povysheva@gmail.com
Россия, Kazan
V. Reznik
Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences
Email: t.povysheva@gmail.com
Россия, Kazan
K. Knni
Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation
Email: t.povysheva@gmail.com
Россия, Kazan
P. Kolesnikov
Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation
Email: t.povysheva@gmail.com
Россия, Kazan
Yu. Chelyshev
Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation
Email: t.povysheva@gmail.com
Россия, Kazan