Interleukin-6 in Sera of Mice Inoculated with Group A Streptococcus and Cultural Supernatants
- Авторы: Danilova T.1, Danilina G.1, Adzhieva A.1, Minko A.1, Zhukhovitskii V.1
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Учреждения:
- Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation
- Выпуск: Том 161, № 6 (2016)
- Страницы: 797-800
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237789
- DOI: https://doi.org/10.1007/s10517-016-3513-0
- ID: 237789
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Аннотация
Dynamics of IL-6 level was studied in blood serum of CBA mice receiving intraperitoneal injections of killed and live culture of group A Streptococcus and its supernatants. It was found that administration of killed culture was followed by a significant rise in IL-6 level (by 4.7 times in 1 h and by 9.3 times in 5 h in comparison with the control). By 24 h, cytokine content was below the control. The highest levels of IL-6 were found after treatment with supernatants of Streptococcus cultures (by 10.5 times in 1 h and by 14.9 times in 5 h, in comparison with the control). Administration of live culture was accompanied by an increase in IL-6 concentration by 3.2 times in 3 h. In this experimental series, the maximum level of IL-6 was found in 48 h (by 5.2 times), and then it gradually decreased below the control. Different dynamics of changes in IL-6 level after administration of killed and live cultures of group A Streptococcus may suggests that they activate different signal pathways.
Об авторах
T. Danilova
Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation
Автор, ответственный за переписку.
Email: dansen@inbox.ru
Россия, Moscow
G. Danilina
Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation
Email: dansen@inbox.ru
Россия, Moscow
A. Adzhieva
Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation
Email: dansen@inbox.ru
Россия, Moscow
A. Minko
Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation
Email: dansen@inbox.ru
Россия, Moscow
V. Zhukhovitskii
Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation
Email: dansen@inbox.ru
Россия, Moscow