Long-Term Effects of Neonatal Pain and Stress on Reactivity of the Nociceptive System
- Авторы: Butkevich I.1, Mikhailenko V.1
-
Учреждения:
- Laboratory of Ontogenesis of the Nervous System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Выпуск: Том 161, № 6 (2016)
- Страницы: 755-758
- Раздел: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237749
- DOI: https://doi.org/10.1007/s10517-016-3502-3
- ID: 237749
Цитировать
Аннотация
The influence of inflammatory pain and/or weaning stress at different terms of neonatal development on functional activity of the nociceptive system during adulthood was studied in rats. Repeated stress in 1-2-day-old rat pups (a premature baby model) enhanced pain sensitivity to peripheral inflammation in both males and females. Repeated inflammatory pain experienced by male pups aged 1-2 or 7-8 days (models of preterm and full-term baby), even in presence of mother, enhanced pain behavior under conditions of repeated inflammatory pain in adulthood. Pain sensitivity in adult animals before (hot plate test) and after formation of the inflammatory focus (formalin test) depended on the age when the animals were subjected to the injury, type of exposure, and on animal sex. The priority data obtained by us will help to understand the mechanisms of long-term effects of early injuries and are important for pediatricians and neonatologists.
Об авторах
I. Butkevich
Laboratory of Ontogenesis of the Nervous System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: irinabutkevich@yandex.ru
Россия, St. Petersburg
V. Mikhailenko
Laboratory of Ontogenesis of the Nervous System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: irinabutkevich@yandex.ru
Россия, St. Petersburg