Neuroprotective and Antiamnestic Effects of a New Drug Emopag in Rats
- Autores: Yasnetsov V.1, Voronina T.2, Skachilova S.3, Yasnetsov V.1
-
Afiliações:
- State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
- V. V. Zakusov Research Institute of Pharmacology
- All-Russian Research Center for Safety of Bioactive Substances
- Edição: Volume 168, Nº 2 (2019)
- Páginas: 247-249
- Seção: New Drugs
- URL: https://journals.rcsi.science/0007-4888/article/view/242383
- DOI: https://doi.org/10.1007/s10517-019-04684-w
- ID: 242383
Citar
Resumo
Emopag, a new drug, preventively administered in doses of 10 and 30 mg/kg/day over 4 days produced a pronounced neuroprotective effect in the model of brain ischemia caused by gravitational overload and reduced animal mortality from 17 to 0%. The preparation more effectively corrected neurological deficit than the reference drugs Mexidol (in considerably larger doses of 30 and 90 mg/kg/day) and antihypoxic drug amtizol (30 mg/kg/day). Moreover, Emopag exhibited considerable antiamnestic activity comparable to that of Mexidol (in 3-fold higher doses); in a dose of 30 mg/kg/day Emopag was more effective than Mexidol and amtizol in the same dose. Thus, Emopag showed marked neuroprotective and antiamnestic effects in the model of gravitational overload in rats.
Sobre autores
V. Yasnetsov
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Autor responsável pela correspondência
Email: vicyas@yandex.ru
Rússia, Moscow
T. Voronina
V. V. Zakusov Research Institute of Pharmacology
Email: vicyas@yandex.ru
Rússia, Moscow
S. Skachilova
All-Russian Research Center for Safety of Bioactive Substances
Email: vicyas@yandex.ru
Rússia, Staraya Kupavna
V. Yasnetsov
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: vicyas@yandex.ru
Rússia, Moscow