Association of DNMT3B and DNMN3L Gene Polymorphisms with Early Pregnancy Loss
- Autores: Azova M.1, Ahmed A.1, Ait Aissa A.1, Blagonravov M.2
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Afiliações:
- Department of Biology and General Genetics
- V. A. Frolov Department of General Pathology and Pathophysiology, Medical Institute, Peoples’ Friendship University of Russia (RUDN University)
- Edição: Volume 167, Nº 4 (2019)
- Páginas: 475-478
- Seção: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/241808
- DOI: https://doi.org/10.1007/s10517-019-04553-6
- ID: 241808
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Resumo
A total of 100 women with early pregnancy loss were recruited and further classified into two subgroups: sporadic pregnancy loss and recurrent pregnancy loss; each subgroup consisted of 50 women. The control group included 56 women with normal pregnancies. Genotyping was performed by PCR with restriction fragment length polymorphism analysis. A statistically significant increase in the frequencies of TT genotype and T allele for DNMT3B rs2424913 polymorphism was found in the total patient group and in both patient subgroups in comparison with the control. Moreover, homozygous TT genotype was associated with increased risk of early pregnancy loss (both sporadic and recurrent). DNMT3B rs2424913 gene polymorphism in women can be used a marker of predisposition to early pregnancy loss and recurrent pregnancy loss.
Sobre autores
M. Azova
Department of Biology and General Genetics
Autor responsável pela correspondência
Email: azovam@mail.ru
Rússia, Moscow
A. Ahmed
Department of Biology and General Genetics
Email: azovam@mail.ru
Rússia, Moscow
A. Ait Aissa
Department of Biology and General Genetics
Email: azovam@mail.ru
Rússia, Moscow
M. Blagonravov
V. A. Frolov Department of General Pathology and Pathophysiology, Medical Institute, Peoples’ Friendship University of Russia (RUDN University)
Email: azovam@mail.ru
Rússia, Moscow