Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior
- Autores: Idova G.1,2, Al’perina E.1, Zhanaeva S.1, Gevorgyan M.1, Rogozhnikova A.2
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Afiliações:
- Research Institute of Physiology and Fundamental Medicine
- Novosibirsk National Research State University
- Edição: Volume 167, Nº 1 (2019)
- Páginas: 11-16
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241409
- DOI: https://doi.org/10.1007/s10517-019-04450-y
- ID: 241409
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Resumo
The content of pro- and anti-inflammatory cytokines in the hypothalamus, hippocampus, and blood serum of C57Bl/6J mice with depressive-like behavior induced by 20-day social stress was analyzed in 4 h after immune stimulation with LPS (250 μg/kg). These animals are characterized by a tendency to an increase in the blood content of IL-6 and a decrease in the level of IL-10. Changes in cytokine content in the brain of mice with depressive-like state developed under these conditions were observed only in the hippocampus: the levels of IL-1β, IL-6, TNFα, and IL-10 increased and the content of IFNγ decreased in comparison the corresponding parameters in the controls (not exposed to social stress) and aggressive animals. No changes in the levels of IL-2, IL-4, and IL-17 were revealed in the hypothalamus and hippocampus.
Sobre autores
G. Idova
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Autor responsável pela correspondência
Email: galina-idova@mail.ru
Rússia, Novosibirsk; Novosibirsk
E. Al’perina
Research Institute of Physiology and Fundamental Medicine
Email: galina-idova@mail.ru
Rússia, Novosibirsk
S. Zhanaeva
Research Institute of Physiology and Fundamental Medicine
Email: galina-idova@mail.ru
Rússia, Novosibirsk
M. Gevorgyan
Research Institute of Physiology and Fundamental Medicine
Email: galina-idova@mail.ru
Rússia, Novosibirsk
A. Rogozhnikova
Novosibirsk National Research State University
Email: galina-idova@mail.ru
Rússia, Novosibirsk