Dynamics of fMRI and EEG Parameters in a Stroke Patient Assessed during a Neurofeedback Course Focused on Brodmann Area 4 (M1)
- Autores: Savelov A.1, Shtark M.2,3,4, Mel’nikov M.2,3, Kozlova L.2,3, Bezmaternykh D.2,3, Verevkin E.2, Petrovskii E.1, Pokrovskii M.1, Tsirkin G.2, Rudych P.5
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Afiliações:
- International Tomography Center, Siberian Division of the Russian Academy of Sciences
- Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine
- Novosibirsk National Research State University
- Research-and-Development Enterprise Komsib
- Research Institute of Computational Technologies, Siberian Division of the Russian Academy of Sciences
- Edição: Volume 166, Nº 3 (2019)
- Páginas: 394-398
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241031
- DOI: https://doi.org/10.1007/s10517-019-04358-7
- ID: 241031
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Resumo
A course of interactive stimulation of primary motor cortex (Brodmann area 4) in the brain of a stroke patient resulted in recovery of locomotion volume in the paretic extremities and in improvement of general health accompanied with diverse changes in cerebral activity. During the training course, the magnitude of response in the visual fields of Brodmann areas 17 and 18 decreased; in parallel, the motor areas were supplemented with other ones such as area 24 (the ventral surface of anterior cingulate gyrus responsible for self-regulation of human brain activity and implicated into synthesis of tactile and special information) in company with Brodmann areas 40, 41, 43, 44, and 45. EEG data showed that neurofeedback sessions persistently increased the θ rhythm power in Brodmann areas 7, 39, 40, and 47, while the corresponding powers progressively decreased during a real motion. Both real motion and its virtual sibling constructed by interactive stimulation via neurofeedback were characterized with decreasing powers of the EEG β rhythm in Brodmann areas 6 and 8. The neurofeedback course decreased the coherence between the left Brodmann area 6 and some other ones examined in α and θ ranges. In the context of real motions, the coherence assessed in the EEG β range generally increased. Overall, the EEG and fMRI parameters attest to growing similarity between the moieties of functional communications effected in real and imaginary movements during neurofeedback course. The data open the vista for interactive stimulation to rehabilitate stroke patients; they highlight the important role of Brodmann areas in rearrangement of the brain in such patients; finally, the present results revealed the “common nervous pathway” that can be used to restore the capability for imaginary and real movements by a neurofeedback course after stroke.
Sobre autores
A. Savelov
International Tomography Center, Siberian Division of the Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk
M. Shtark
Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine; Novosibirsk National Research State University; Research-and-Development Enterprise Komsib
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk; Novosibirsk; Novosibirsk
M. Mel’nikov
Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine; Novosibirsk National Research State University
Autor responsável pela correspondência
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk; Novosibirsk
L. Kozlova
Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine; Novosibirsk National Research State University
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk; Novosibirsk
D. Bezmaternykh
Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine; Novosibirsk National Research State University
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk; Novosibirsk
E. Verevkin
Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk
E. Petrovskii
International Tomography Center, Siberian Division of the Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk
M. Pokrovskii
International Tomography Center, Siberian Division of the Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk
G. Tsirkin
Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk
P. Rudych
Research Institute of Computational Technologies, Siberian Division of the Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
Rússia, Novosibirsk