Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from  Tussilago farfara  L.

E. A. Safonova; K. A. Lopatina; T. G. Razina; E. P. Zueva; E. P. Fedorova; A. M. Gur’ev; M. V. Belousov

doi:10.1007/s10517-018-4313-5

Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.

Autores: Safonova E.¹, Lopatina K.¹, Razina T.¹, Zueva E.¹, Fedorova E.¹, Gur’ev A.², Belousov M.²
Afiliações:
1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
2. Siberian State Medical University, Ministry of Health of the Russian Federation
Edição: Volume 166, Nº 2 (2018)
Páginas: 197-200
Seção: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240905
DOI: https://doi.org/10.1007/s10517-018-4313-5
ID: 240905

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The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.