Effect of Mesenchymal Stromal Cells and Conditioned Media on Healing of Skin Wound
- Autores: Payushina O.1, Butorina N.1, Sheveleva O.1, Domaratskaya E.1
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Afiliações:
- N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences
- Edição: Volume 165, Nº 4 (2018)
- Páginas: 572-575
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240545
- DOI: https://doi.org/10.1007/s10517-018-4215-6
- ID: 240545
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Resumo
We studied the effect of mesenchymal stromal cells and conditioned media on healing of full-thickness skin wound in rats. Cell transplantation to the wound bed did not accelerate wound closing and had no effect on the severity of inflammation, but increased vasculariza - tion of the granulation tissue in 14 days after injury. After injection of conditioned medium to the wound, less pronounced inflammation or enhanced epithelialization was observed. The angiogenic effect was observed only after repeated administration of conditioned medium and was associated with slower regeneration, probably due to skin traumatization by repeated injections. At the same time, fetal skin fibroblasts stimulated angiogenesis only after transplantation in high doses and the medium conditioned by these fibroblasts had no effect on wound healing.
Sobre autores
O. Payushina
N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences
Autor responsável pela correspondência
Email: payushina@mail.ru
Rússia, Moscow
N. Butorina
N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences
Email: payushina@mail.ru
Rússia, Moscow
O. Sheveleva
N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences
Email: payushina@mail.ru
Rússia, Moscow
E. Domaratskaya
N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences
Email: payushina@mail.ru
Rússia, Moscow
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