Structure of Interneuronal Contacts in the Neuropil of the Oculomotor Nuclei in Mouse Brain under Conditions of Long-Term Microgravity
- Autores: Mikheeva I.1, Shtanchaev R.1, Pen’kova N.1, Pavlik L.1
-
Afiliações:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Edição: Volume 165, Nº 4 (2018)
- Páginas: 457-460
- Seção: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/240415
- DOI: https://doi.org/10.1007/s10517-018-4193-8
- ID: 240415
Citar
Resumo
Ultrastructure of the neuropil of the brain oculomotor nuclei was studied in mice after 30-day exposure to microgravity on Bion-M1 biosatellite and after 13-h exposure to Earth gravity. The number of axo-dendritic synapses in the neuropil of the oculomotor nucleus significantly decreased after the flight. Degenerated axon terminals containing conglomerates of presynaptic vesicles appeared. The number of synapses with high functional activity increased and the length of active zones of the axo-dendritic synapses significantly increased. The observed ultrastructural changes of the neuropil of the oculomotor nuclei of mice exposed to microgravity reflect the development of long-term deafferentation of the analyzed brain structures. These changes in the neuropil ultrastructure can determine the disturbances in the oculomotor system, e.g. development of atypical nystagmus under conditions of microgravity.
Sobre autores
I. Mikheeva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Autor responsável pela correspondência
Email: mikheirina@yandex.ru
Rússia, Pushchino, Moscow Region
R. Shtanchaev
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: mikheirina@yandex.ru
Rússia, Pushchino, Moscow Region
N. Pen’kova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: mikheirina@yandex.ru
Rússia, Pushchino, Moscow Region
L. Pavlik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: mikheirina@yandex.ru
Rússia, Pushchino, Moscow Region