Hypolipidemic and Hepatoprotective Effects of a Polyprenol-Containing Drug in Patients with Acute Coronary Syndrome
- Autores: Vyshlov E.1, Tsoy E1, Sultanov V.2, Trusov V.3, Ryabov V.1
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Afiliações:
- Cardiology Research Institute, Tomsk National Research Medical Center
- Prenolica Limited
- Solagift Company
- Edição: Volume 165, Nº 3 (2018)
- Páginas: 319-321
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240262
- DOI: https://doi.org/10.1007/s10517-018-4159-x
- ID: 240262
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Resumo
In a double-blind placebo-controlled trial POLYNCOR (registration No. NCT03122340 at clinicaltrials.gov), lipid-lowering and hepatoprotective effects of polyprenol-containing drug Ropren were evaluated in patients with acute coronary syndrome. After 2-months therapy, total cholesterol and ALT in the patients receiving Ropren were significantly (p<0.05) lower than in the control group. The number of patients who needed to discontinue or reduce the dose of atorvastatin due to an increase in the level of transaminases in the main group was significantly (p<0.05) lower than in the control group: 0 (0%) vs. 5 (33.3%). The more pronounced decrease in cholesterol level and hepatoprotective effect of Ropren allowed recommending this preparation to patients with acute coronary syndrome in addition to standard therapy.
Sobre autores
E. Vyshlov
Cardiology Research Institute, Tomsk National Research Medical Center
Autor responsável pela correspondência
Email: evv@cardio-tomsk.ru
Rússia, Tomsk
E Tsoy
Cardiology Research Institute, Tomsk National Research Medical Center
Email: evv@cardio-tomsk.ru
Rússia, Tomsk
V. Sultanov
Prenolica Limited
Email: evv@cardio-tomsk.ru
Austrália, Melbourne
V. Trusov
Solagift Company
Email: evv@cardio-tomsk.ru
Rússia, Tomsk
V. Ryabov
Cardiology Research Institute, Tomsk National Research Medical Center
Email: evv@cardio-tomsk.ru
Rússia, Tomsk