Injection of Multipotent Mesenchymal Stromal Cells as a Cause of Hemorrhages in the Regional Lymph Nodes: Experimental Study
- Autores: Maiborodin I.1, Morozov V.1, Anikeev A.1, Figurenko N.1, Maslov R.1, Matveeva V.1, Maiborodina V.2
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Afiliações:
- Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Laboratory of Ultrastructural Bases of Pathology, Institute of Molecular Pathology and Pathomorphology
- Edição: Volume 164, Nº 6 (2018)
- Páginas: 784-789
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239910
- DOI: https://doi.org/10.1007/s10517-018-4080-3
- ID: 239910
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Resumo
Hemorrhagic changes after subcutaneous injection of autologous bone marrow multipotent mesenchymal cells with transfected GFP gene and additionally stained cell membranes to WAG rats in the projection of ligated femoral vein were studied by fluorescent microscopy. Hemorrhages in tissues with experimental acute local venous occlusion were caused by a combination of venous hypertension with inflammation around the foreign body — the ligature used for ligation of the vein. Fibrin found in tissues together with erythrocytes in the hemorrhages could stimulate the formation of granulations and new vessels instead of damaged or thrombosed ones. Multipotent mesenchymal stromal cells and their detritus getting into the regional lymph nodes initiated immune reactions morphologically confirmed by stubborn hypertrophy and hyperplasia of the lymphoid nodules, hemorrhages, and manifest diapedesis of erythrocytes to the organ parenchyma and sinus system.
Sobre autores
I. Maiborodin
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: imai@mail.ru
Rússia, Novosibirsk
V. Morozov
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Rússia, Novosibirsk
A. Anikeev
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Rússia, Novosibirsk
N. Figurenko
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Rússia, Novosibirsk
R. Maslov
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Rússia, Novosibirsk
V. Matveeva
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Rússia, Novosibirsk
V. Maiborodina
Laboratory of Ultrastructural Bases of Pathology, Institute of Molecular Pathology and Pathomorphology
Email: imai@mail.ru
Rússia, Novosibirsk