Changes in Activity of Cysteine Cathepsins B and L in Brain Structures of Mice with Aggressive and Depressive-Like Behavior Formed under Conditions of Social Stress
- Autores: Zhanaeva S.1, Rogozhnikova A.2, Alperina E.1, Gevorgyan M.1, Idov G.1,2
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Afiliações:
- Research Institute of Physiology and Fundamental Medicine
- Novosibirsk National Research State University
- Edição: Volume 164, Nº 4 (2018)
- Páginas: 425-429
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239664
- DOI: https://doi.org/10.1007/s10517-018-4004-2
- ID: 239664
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Resumo
We studied activity of lysosomal cysteine proteases, cathepsins B and L, in brain structures (frontal cortex, caudate nucleus, hippocampus, and hypothalamus) of C57Bl/6J mice with aggressive and depressive-like behavior formed under conditions of chronic social stress (repeated experience of victories and defeats within 20 days). Mice with depressive-like behavior showed increased activity of cathepsin В in the hypothalamus and nucleus caudatus and increased activity of cathepsin L in the hippocampus compared to control animals not subjected to agonistic confrontations. In mice with aggressive behavior, protease activity in the studied brain structures was not changed. In 4 h after immune system activation with LPS (250 μg/kg), cathepsin L activity in the hippocampus of control mice increased in comparison with mice receiving saline. In contrast to control animals, LPS caused a decrease in activity of the enzyme in the caudate nucleus and frontal cortex of aggressive mice and in the hippocampus of mice with depressive-like behavior.
Sobre autores
S. Zhanaeva
Research Institute of Physiology and Fundamental Medicine
Autor responsável pela correspondência
Email: s.zhanaeva@physiol.ru
Rússia, Novosibirsk
A. Rogozhnikova
Novosibirsk National Research State University
Email: s.zhanaeva@physiol.ru
Rússia, Novosibirsk
E. Alperina
Research Institute of Physiology and Fundamental Medicine
Email: s.zhanaeva@physiol.ru
Rússia, Novosibirsk
M. Gevorgyan
Research Institute of Physiology and Fundamental Medicine
Email: s.zhanaeva@physiol.ru
Rússia, Novosibirsk
G. Idov
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Email: s.zhanaeva@physiol.ru
Rússia, Novosibirsk; Novosibirsk