Role of NF-κB, PI3K, MAPK/ERK 1/2, and p38 in Erythropoietin Production by Bone Marrow Nuclears under Conditions of Immobilization Stress
- Autores: Miroshnichenko L.1, Zhdanov V.1, Udut E.1, Polyakova T.1, Zyuz’kov G.1, Simanina E.1, Sherstoboev E.1, Stavrova L.1, Agafonov V.1, Minakova M.1, Chaikovskii A.1, Dygai A.1
-
Afiliações:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
- Edição: Volume 163, Nº 3 (2017)
- Páginas: 352-355
- Seção: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/238888
- DOI: https://doi.org/10.1007/s10517-017-3802-2
- ID: 238888
Citar
Resumo
The involvement of the studied signal cascades in the regulation of erythropoietin production by bone marrow nuclears under conditions of immobilization stress depends on the type of the hemopoiesis-inducing microenvironment cells and the period of blood system reaction to stress exposure. Secretory activity of monocytes is regulated mainly by PI3K improving cell resistance to disturbances. The functional role of signal cascades involved in the production of erythropoietin by T cells is determined by the stage of the common adaptation syndrome.
Sobre autores
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Autor responsável pela correspondência
Email: laarmi@yandex.ru
Rússia, Tomsk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
E. Sherstoboev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
L. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
V. Agafonov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
M. Minakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
A. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: laarmi@yandex.ru
Rússia, Tomsk