Regulation of Primary Polymerization of Fibrin by Blood Anticoagulant System Components
- Autores: Lyapina L.1, Maistrenko E.1
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Afiliações:
- Department of Human and Animal Physiology, Faculty of Biology, M. V. Lomonosov Moscow State University
- Edição: Volume 163, Nº 1 (2017)
- Páginas: 46-48
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238634
- DOI: https://doi.org/10.1007/s10517-017-3734-x
- ID: 238634
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Resumo
Experimental data on the involvement of the blood anticoagulant system components (heparin complex compounds, short regulatory peptides) in fibrin formation processes are presented. Inhibition of thrombin activity and interactions of short glyproline peptides and their heparin complexes with fibrin monomer molecules are demonstrated. Peptides and their heparin complexes prevent the formation of primary polymeric fibrin and exhibit fibrin-depolymerizing activity on the formed polymeric fibrin. The mechanisms underlying the effects of heparin complexes on degradation of fibrin not stabilized with factor XIIIa is discussed on the basis of the results of spectral analysis and coagulation tests.
Sobre autores
L. Lyapina
Department of Human and Animal Physiology, Faculty of Biology, M. V. Lomonosov Moscow State University
Autor responsável pela correspondência
Email: lyapinal@mail.ru
Rússia, Moscow
E. Maistrenko
Department of Human and Animal Physiology, Faculty of Biology, M. V. Lomonosov Moscow State University
Email: lyapinal@mail.ru
Rússia, Moscow