Effects of Afobazole on Postnatal Development of Rat Offspring
- Autores: Denisova T.1, Sergeeva S.1, Morozova Y.1, Kharlamov I.1, Bugaeva L.1
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Afiliações:
- Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation
- Edição: Volume 162, Nº 4 (2017)
- Páginas: 441-444
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/238284
- DOI: https://doi.org/10.1007/s10517-017-3635-z
- ID: 238284
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Resumo
Physical development, development of sensory and motor reflexes, behavioral and mnestic patterns were studied infantile and juvenile rat pups born by female rats receiving Afobazole during pregnancy. Physical development and development of sensory and motor reflexes in rats were completed without pathologies by the age of 2 months. During the infantile period, the rat pups demonstrated reduced body weight gain, delayed eye opening and pupillary response formation, decreased muscle force, and suppressed motor behavior. During the juvenile period, body weight gain and development of motor behavior were intensified. Females demonstrated later vagina opening and poorer mnestic responses. In males, the terms of sexual maturation were unchanged and processes of learning and memory retrieval were not impaired.
Sobre autores
T. Denisova
Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: lb.bugaeva@rambler.ru
Rússia, Volgograd
S. Sergeeva
Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: lb.bugaeva@rambler.ru
Rússia, Volgograd
Yu. Morozova
Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: lb.bugaeva@rambler.ru
Rússia, Volgograd
I. Kharlamov
Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: lb.bugaeva@rambler.ru
Rússia, Volgograd
L. Bugaeva
Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: lb.bugaeva@rambler.ru
Rússia, Volgograd