Effects of NO Synthase Blocker L-NAME on Functional State of the Neuromotor System during Traumatic Disease of the Spinal Cord
- Authors: Yafarova G.G.1,2,3, Andrianov V.V.1,3, Yagudin R.K.2, Shaikhytdinov I.I.2, Gainutdinov K.L.1,3
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Affiliations:
- Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University
- Republican Clinical Hospital, Ministry of Health of Tatarstan Republic
- Kazan Physical-Technical Institute, Kazan Research Center of the Russian Academy of Sciences
- Issue: Vol 162, No 3 (2017)
- Pages: 316-319
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238159
- DOI: https://doi.org/10.1007/s10517-017-3604-6
- ID: 238159
Cite item
Abstract
Functional state of the neuromotor system after administration of a nonspecific NO synthase blocker L-NAME was studied on the model of experimental contusion of the spinal cord. Electron paramagnetic resonance measurements of NO production in the damaged segment of the spinal cord were performed for estimation of the dynamics of intensity of NO production during traumatic disease of the spinal cord and selection of optimal period for L-NAME administration. The status of the neuromotor system was evaluated by stimulation electromyography. Treatment with L-NAME during the acute period of traumatic injury to the spinal cord sharply reduced the intensity of evoked motor responses and more pronounced increase in excitability of peripheral motor structures. The results suggest that NO system is a factor of regulation of the stress-induced and adaptive responses of the body at the early stage of spinal cord injury.
About the authors
G. G. Yafarova
Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University; Republican Clinical Hospital, Ministry of Health of Tatarstan Republic; Kazan Physical-Technical Institute, Kazan Research Center of the Russian Academy of Sciences
Email: kh_gainutdinov@mail.ru
Russian Federation, Kazan; Kazan; Kazan, Tatarstan Republic
V. V. Andrianov
Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University; Kazan Physical-Technical Institute, Kazan Research Center of the Russian Academy of Sciences
Email: kh_gainutdinov@mail.ru
Russian Federation, Kazan; Kazan, Tatarstan Republic
R. Kh. Yagudin
Republican Clinical Hospital, Ministry of Health of Tatarstan Republic
Email: kh_gainutdinov@mail.ru
Russian Federation, Kazan
I. I. Shaikhytdinov
Republican Clinical Hospital, Ministry of Health of Tatarstan Republic
Email: kh_gainutdinov@mail.ru
Russian Federation, Kazan
Kh. L. Gainutdinov
Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University; Kazan Physical-Technical Institute, Kazan Research Center of the Russian Academy of Sciences
Author for correspondence.
Email: kh_gainutdinov@mail.ru
Russian Federation, Kazan; Kazan, Tatarstan Republic