Hypotensive Effect and Accumulation of Dinitrosyl Iron Complexes in Blood and Tissues after Intravenous and Subcutaneous Injection
- Autores: Timoshin A.1, Lakomkin V.1, Abramov A.1, Ruuge E.1, Vanin A.2
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Afiliações:
- Research Institute of Experimental Cardiology of Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
- N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
- Edição: Volume 162, Nº 2 (2016)
- Páginas: 207-210
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/238038
- DOI: https://doi.org/10.1007/s10517-016-3577-x
- ID: 238038
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Resumo
Subcutaneous injection of Oxacom with glutathione-bound dinitrosyl iron complex as the active principle produced a slower drop of mean BP and longer accumulation of protein-bound dinitrosyl iron complexes in whole blood and tissues than intravenous injection of this drug, while durations of hypotensive effect in both cases were practically identical. In contrast to intravenous injection of the drug, its subcutaneous administration was not characterized by a high concentration of protein-bound dinitrosyl iron complexes in the blood at the onset of experiment; in addition, accumulation of these NO forms in the lungs was more pronounced after subcutaneous injection than after intravenous one.
Sobre autores
A. Timoshin
Research Institute of Experimental Cardiology of Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: bbm.ktbm@gmail.com
Rússia, Moscow
V. Lakomkin
Research Institute of Experimental Cardiology of Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: bbm.ktbm@gmail.com
Rússia, Moscow
A. Abramov
Research Institute of Experimental Cardiology of Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: bbm.ktbm@gmail.com
Rússia, Moscow
E. Ruuge
Research Institute of Experimental Cardiology of Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: bbm.ktbm@gmail.com
Rússia, Moscow
A. Vanin
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: bbm.ktbm@gmail.com
Rússia, Moscow