Enviar artigo por via de e-mail Interaction of Lymphocytes with Mesenchymal Stem Cells
- Autores: Svirshchevskaya E.1, Poltavtseva R.2, Beletskii I.3, Selezneva I.3, Savilova A.2, Sukhikh G.2
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Afiliações:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Edição: Volume 161, Nº 4 (2016)
- Páginas: 571-579
- Seção: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/237601
- DOI: https://doi.org/10.1007/s10517-016-3463-6
- ID: 237601
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Resumo
We studied the interaction of neural stem cells and dental pulp-derived mesenchymal stem cells with lymphocytes from autologous and heterologous donors. Flow cytometry analysis with the use of CFSE-labeled lymphocytes demonstrated an increase in the content of proliferating CD8, CD16 and CD56 cells, but not CD4 cells in cultures of HLA-DR-negative mesenchymal stromal cells from the dental pulp co-cultured with lymphocytes. In neural cultures expressing HLA-DR, all subpopulations of T cells and NK cells were activated. No differences between the autologous and heterologous cultures were revealed.
Sobre autores
E. Svirshchevskaya
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Autor responsável pela correspondência
Email: esvir@mx.ibch.ru
Rússia, Moscow
R. Poltavtseva
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: esvir@mx.ibch.ru
Rússia, Moscow
I. Beletskii
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: esvir@mx.ibch.ru
Rússia, Pushchino, Moscow Region
I. Selezneva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: esvir@mx.ibch.ru
Rússia, Pushchino, Moscow Region
A. Savilova
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: esvir@mx.ibch.ru
Rússia, Moscow
G. Sukhikh
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: esvir@mx.ibch.ru
Rússia, Moscow
