Regulatory Proteins of Epithelial-Mesenchymal Transition and Some Components of VEGF Signaling Pathway in Breast Cancer
- Autores: Scherbakov A.1, Gershtein E.1, Korotkova E.1, Ovchinnikova L.1, Ovsii O.1, Ermilova V.1, Gens G.1, Kushlinskii N.1
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Afiliações:
- N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
- Edição: Volume 160, Nº 6 (2016)
- Páginas: 802-806
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236956
- DOI: https://doi.org/10.1007/s10517-016-3314-5
- ID: 236956
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Resumo
Immunohistochemical method was used to assay for Snail family regulatory proteins of epithelial-mesenchymal transition, their NF-κB coactivator, and the components of VEGF signaling pathway (VEGF and its receptors VEGFR1 and VEGFR2) in 157 specimens of breast tumors. Most tumors did not express SNAI1, while 65% tumors demonstrated mid- or high-level SNAI2 expression. There were significant correlations between the expression of SNAI1, SNAI2, and their NF-κB co-activator. Correlation was also detected between expression of Snail and VEGFR1 protein families in the tumors. In addition, the study revealed tumoral co-expression of SNAI2 and VEGFR2. The data attest to coordinated activation of regulatory proteins of epithelial-mesenchymal transition and the major components of VEGF signaling pathway in breast tumors.
Sobre autores
A. Scherbakov
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: alex.scherbakov@gmail.com
Rússia, Moscow
E. Gershtein
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: alex.scherbakov@gmail.com
Rússia, Moscow
E. Korotkova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: alex.scherbakov@gmail.com
Rússia, Moscow
L. Ovchinnikova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: alex.scherbakov@gmail.com
Rússia, Moscow
O. Ovsii
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: alex.scherbakov@gmail.com
Rússia, Moscow
V. Ermilova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: alex.scherbakov@gmail.com
Rússia, Moscow
G. Gens
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: alex.scherbakov@gmail.com
Rússia, Moscow
N. Kushlinskii
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: alex.scherbakov@gmail.com
Rússia, Moscow
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