Immunistochemical Analysis of the Expression of TGFβ, Galectin-1, Vimentin, and Thrombospondin in Gastric Cancer Associated with Systemic Undifferentiated Connective Tissue Dysplasia
- Авторлар: Naumova L.1, Osipova O.1, Klinnikova M.2
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Мекемелер:
- Institute of Medicine, Surgut State University
- Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine
- Шығарылым: Том 166, № 6 (2019)
- Беттер: 774-778
- Бөлім: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/241358
- DOI: https://doi.org/10.1007/s10517-019-04438-8
- ID: 241358
Дәйексөз келтіру
Аннотация
We performed immunohistochemical analysis of the expression of TGFβ, galectin-1, vimentin, and thrombospondin in the mucosa in gastric cancer of diffuse and intestinal type associated with systemic undifferentiated connective tissue dysplasia. In diffuse gastric cancer, both with and without association with connective tissue dysplasia, a higher level of expression of TGFβ, galectin-1, vimentin, and thrombospondin in the tumor was detected in comparison with the perifocal and tumor zones in intestinal gastric cancer, which may reflect the pathogenetic peculiarities of the two histotypes of gastric cancer. Intestinal type of gastric cancer associated with connective tissue dysplasia is characterized by a high level of expression of galectin-1 and vimentin in the perifocal zone and TGFβ in the tumor zone. The pattern of expression of the studied markers can reflect both the pathogenetic peculiarities of the two histotypes of gastric cancer and peculiar expression of some growth factors, cytoskeleton proteins, and matrix-cell proteins associated with undifferentiated connective tissue dysplasia which may contribute to epithelial—mesenchymal transition.
Авторлар туралы
L. Naumova
Institute of Medicine, Surgut State University
Email: pathol@inbox.ru
Ресей, Surgut
O. Osipova
Institute of Medicine, Surgut State University
Email: pathol@inbox.ru
Ресей, Surgut
M. Klinnikova
Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine
Хат алмасуға жауапты Автор.
Email: pathol@inbox.ru
Ресей, Novosibirsk