Correlations between Extracellular Matrix Components in Mouse Lungs during Chronic BCG-Induced Granulomatosis
- Авторлар: Kim L.1, Shkurupy V.1,2, Putyatina A.1
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Мекемелер:
- Research Institute of Experimental and Clinical Medicine, Ministry of Health of the Russian Federation
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 165, № 3 (2018)
- Беттер: 302-306
- Бөлім: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/240252
- DOI: https://doi.org/10.1007/s10517-018-4155-1
- ID: 240252
Дәйексөз келтіру
Аннотация
Correlations between extracellular matrix components in mouse lungs were examined during various terms of BCG-induced granulomatosis (on postinfection days 3, 30, 60, 90, and 180). During the development of pathological process, the revealed dynamic interrelations between structural units of proteoglycans and hydroxyproline weakened. Most correlations were observed on postinfection day 180. They reflect the relationships not only between the structural units of proteoglycans but also between collagens, presumably determining the maximum degree of fibrosis at this period. The established correlations characterize the systemic nature of reactions in extracellular matrix and its versatile implications determined by the processes going on in the organs and tissues during the onset and development of generalized pathology.
Авторлар туралы
L. Kim
Research Institute of Experimental and Clinical Medicine, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: lenkim@centercem.ru
Ресей, Novosibirsk
V. Shkurupy
Research Institute of Experimental and Clinical Medicine, Ministry of Health of the Russian Federation; Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: lenkim@centercem.ru
Ресей, Novosibirsk; Novosibirsk
A. Putyatina
Research Institute of Experimental and Clinical Medicine, Ministry of Health of the Russian Federation
Email: lenkim@centercem.ru
Ресей, Novosibirsk