Anterograde Amnesia Induced by Disruption of Consolidation or Reconsolidation of Long-Term Memory
- Авторлар: Nikitin V.1, Solntseva S.1, Kozyrev S.1
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Мекемелер:
- P. K. Anokhin Research Institute of Normal Physiology
- Шығарылым: Том 164, № 1 (2017)
- Беттер: 1-5
- Бөлім: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239315
- DOI: https://doi.org/10.1007/s10517-017-3912-x
- ID: 239315
Дәйексөз келтіру
Аннотация
Mechanisms of amnesia caused by impairment of consolidation or reconsolidation of conditioned food aversion memory with protein synthesis inhibitor cycloheximide were studied in Helix lucorum. Cycloheximide injection during training or memory reconsolidation in trained snails produced amnesia. In both cases, repeated training 10 days after amnesia induction led to short-term memory formation, while long-term memory was not formed, despite the fact that the number of conditioned and reinforcing stimuli combinations was higher than during initial training. The possibility of formation of short-term memory not transforming into long-term memory is one of the key characteristics of anterograde amnesia. Our findings data and experimental model can be used for analysis of specific molecular mechanisms of anterograde amnesia.
Авторлар туралы
V. Nikitin
P. K. Anokhin Research Institute of Normal Physiology
Хат алмасуға жауапты Автор.
Email: nikitin.vp@mail.ru
Ресей, Moscow
S. Solntseva
P. K. Anokhin Research Institute of Normal Physiology
Email: nikitin.vp@mail.ru
Ресей, Moscow
S. Kozyrev
P. K. Anokhin Research Institute of Normal Physiology
Email: nikitin.vp@mail.ru
Ресей, Moscow