Expression of Flk-1 and Cyclin D2 mRNA in the Myocardium of Rats with Doxorubicin-Induced Cardiomyopathy and after Treatment with Betulonic Acid Amide
- Авторлар: Mzhelskaya M.1, Klinnikova M.1, Koldysheva E.1, Lushnikova E.1
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Мекемелер:
- Institute of Molecular Pathology and Pathomorphology
- Шығарылым: Том 163, № 6 (2017)
- Беттер: 809-813
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239294
- DOI: https://doi.org/10.1007/s10517-017-3909-5
- ID: 239294
Дәйексөз келтіру
Аннотация
The expression of VEGFR2 (Flk-1, according to immunohistochemistry) and of cyclin D2 mRNA (according to real-time PCR) in the myocardium of rats is studied in doxorubicin-induced cardiomyopathy and in response to betulonic acid amide. Doxorubicin alone and in combination with betulonic acid amide causes after 3 days a manifest reduction of cyclin D2 mRNA expression (by 38 and 63%, respectively), while injection of betulonic acid amide alone causes a 23-fold increase of cyclin D2 mRNA expression. An increase of cyclin D2 mRNA expression has been detected in all experimental groups after 14 days of experiment, the most pronounced in response to betulonic acid amide (63 times). The expression of Flk-1 in cardiomyocytes increases significantly in response to both chemical agents starting from day 3 of experiment. These results indicate that doxorubicin and betulonic acid amide induce cytoprotective reactions in the myocardium, first at the intracellular, then at the cellular levels.
Авторлар туралы
M. Mzhelskaya
Institute of Molecular Pathology and Pathomorphology
Хат алмасуға жауапты Автор.
Email: pathol@inbox.ru
Ресей, Novosibirsk
M. Klinnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
E. Koldysheva
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
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