Initial Stages of Angiogenesis after Acute Experimental Local Venous Outflow Disturbances and Application of Cell Technologies
- Авторлар: Maiborodin I.1, Morozov V.1, Matveeva V.1, Anikeev A.1, Maslov R.1, Chastikin G.1, Figurenko N.1
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Мекемелер:
- Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Шығарылым: Том 163, № 1 (2017)
- Беттер: 142-147
- Бөлім: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/238714
- DOI: https://doi.org/10.1007/s10517-017-3755-5
- ID: 238714
Дәйексөз келтіру
Аннотация
The initial stages of angiogenesis in rats after transcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and stained cell membranes in the projection of ligated femoral vein were studied by fluorescent light and confocal laser microscopy. Large clusters of brightly fluorescing elongated fibroblast-like cells were seen in the paravasal tissue and in the postoperative scar and signs of angiogenesis were noted as soon as in 4 days. The injected cells not only formed new vessels, but also integrated into vessels formed by host cells. Some injected cells were phagocytizied by macrophages and the latter started to fluoresce due to the presence of the membrane dye. These macrophages within the specified period appeared in the regional inguinal lymph nodes where they formed clusters in the lymphoid parenchyma of the cortical substance.
Авторлар туралы
I. Maiborodin
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: imai@mail.ru
Ресей, Novosibirsk
V. Morozov
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Ресей, Novosibirsk
V. Matveeva
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Ресей, Novosibirsk
A. Anikeev
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Ресей, Novosibirsk
R. Maslov
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Ресей, Novosibirsk
G. Chastikin
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Ресей, Novosibirsk
N. Figurenko
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Ресей, Novosibirsk