Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension
- Авторлар: Eliseeva E.1, Romanchenko E.1, Dyuizen I.1, Tyrtyshnikova A.1, Pigolkin Y.2
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Мекемелер:
- Department of General and Clinical Pharmacology, Pacific State Medical University
- Department of Forensic Medicine, I. M. Sechenov First Moscow State Medical University
- Шығарылым: Том 162, № 3 (2017)
- Беттер: 357-361
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238205
- DOI: https://doi.org/10.1007/s10517-017-3615-3
- ID: 238205
Дәйексөз келтіру
Аннотация
An original model of nephrogenic hypertension in rats was used for histochemical mapping of NADPH diaphorase (NO synthase) in various renal segments to examine the effect of hypotensive drugs furosemide, bendazol, and clonidine on the time course of nitroxide production in the kidneys. In various nephron segments, these drugs modulated NO synthesis in different ways. Clonidine induced a stable up-regulation of NO synthesis, which can maintain active vasodilation and gradually diminish the rennin production. Bendazol also enhanced NO synthase activity in renal glomeruli and collecting tubules, but this effect was less pronounced and short lasting. During the first week after injection of bendazol, insignificant elevation of NO synthase activity was observed in the proximal nephron segments. Furosemide exerted the least effect on NO production in kidneys.
Авторлар туралы
E. Eliseeva
Department of General and Clinical Pharmacology, Pacific State Medical University
Хат алмасуға жауапты Автор.
Email: yeliseeff@rbcmail.ru
Ресей, Vladivostok
E. Romanchenko
Department of General and Clinical Pharmacology, Pacific State Medical University
Email: yeliseeff@rbcmail.ru
Ресей, Vladivostok
I. Dyuizen
Department of General and Clinical Pharmacology, Pacific State Medical University
Email: yeliseeff@rbcmail.ru
Ресей, Vladivostok
A. Tyrtyshnikova
Department of General and Clinical Pharmacology, Pacific State Medical University
Email: yeliseeff@rbcmail.ru
Ресей, Vladivostok
Yu. Pigolkin
Department of Forensic Medicine, I. M. Sechenov First Moscow State Medical University
Email: yeliseeff@rbcmail.ru
Ресей, Moscow
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