Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model
- Авторлар: Antipova T.1, Nikolaev S.1, Ostrovskaya P.1, Gudasheva T.1, Seredenin S.1
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Мекемелер:
- V. V. Zakusov Research Institute of Pharmacology
- Шығарылым: Том 161, № 1 (2016)
- Беттер: 58-60
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237091
- DOI: https://doi.org/10.1007/s10517-016-3344-z
- ID: 237091
Дәйексөз келтіру
Аннотация
Effect of noopept (N-phenylacetyl-prolylglycine ethyl ester) on viability of neurons exposed to neurotoxic action of glutamic acid (5 mM) was studied in vitro in immortalized mouse hippocampal HT-22 neurons. Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10–11-10–5 M. Comparison of the effective noopept concentrations determined in previous studies on cultured cortical and cerebellar neurons showed that hippocampal neurons are more sensitive to the protective effect of noopept.
Авторлар туралы
T. Antipova
V. V. Zakusov Research Institute of Pharmacology
Email: cergej.nikolajev@gmail.com
Ресей, Moscow
S. Nikolaev
V. V. Zakusov Research Institute of Pharmacology
Хат алмасуға жауапты Автор.
Email: cergej.nikolajev@gmail.com
Ресей, Moscow
P. Ostrovskaya
V. V. Zakusov Research Institute of Pharmacology
Email: cergej.nikolajev@gmail.com
Ресей, Moscow
T. Gudasheva
V. V. Zakusov Research Institute of Pharmacology
Email: cergej.nikolajev@gmail.com
Ресей, Moscow
S. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: cergej.nikolajev@gmail.com
Ресей, Moscow